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Lawrence A. Hansen: Animal experiments won’t help humans with Alzheimer’s

By Lawrence A. Hansen

The Society for Neuroscience recently held its annual conference in Chicago.

I attended not as a member, though neuroscience is my field, but to protest the organization’s stated goal of broadening support for animal research. The society, like animal experimenters everywhere, perceives “growing threats” to animal research and seeks to recruit additional allies with a “vested interest” in promoting animal experimentation.

Every vested interest is entitled to its own propaganda, but such an effort warrants a response from neuroscience researchers who instead advocate kindness to animals.

Neuroscientists with established research credentials and a People for the Ethical Treatment of Animals membership are rare. They are often viewed by faculty colleagues as untrustworthy or even treasonous agents provocateurs as they are inclined to raise both scientific and ethical objections to the most egregious abuses of animals within our own universities. Yet medical school faculty members who are also animal activists are uniquely well-qualified to expose basic scientists’ disingenuous, misleading, or overreaching claims their animal research is scientifically and ethically justified because the results may someday, somehow, possibly benefit humans.

Contrived connections between cruelty-intensive basic neuroscience research and future human welfare is a tacit admission by neuroscientists the general public, which ultimately funds most research, would recoil in horror from their more grotesque monkey, dog, or cat experiments and overwhelmingly condemn them if they knew they were not going to help humans.

One particularly egregious example is a decades-long series of highly invasive monkey experiments performed at universities across the country to study neural control of visual tracking. Luckless monkeys have coils implanted in both eyes, multiple craniotomies for electrode placements in their brains, and head immobilization surgeries in which screws, bolts, and plates are directly attached to their skulls. This is followed by water deprivation to produce a “work ethic” so they will visually track moving objects.

First impressions are usually correct in questions of cruelty to animals, and most of us cannot even bear to look at pictures of these monkeys with their electrode-implanted brains and bolted heads being put through their paces in a desperate attempt to get a life-sustaining sip of water.

Such cruelty is justified in the corresponding grant application by invoking the possibility the resulting data may allow us to find the cause and cure for diseases such as Alzheimer’s. But we who have spent decades in Alzheimer’s disease research recognize such a blank-check justification as an ethical bait-and-switch since this neural pathway is not even involved in Alzheimer’s disease and these experiments have never been referenced in real Alzheimer’s disease research!

Because such monkey torture will not lead to improved human health, you don’t need to be an animal rights advocate to wonder if an ethical cost-benefit analysis might conclude the ends just don’t justify the means, especially since rapid advances in sophisticated high-resolution neuroimaging on humans will very soon obviate the need for such invasive techniques.

Because grant money comes with animal research, the Institutional Animal Care and Use Committees mandated by the U.S. Animal Welfare Act to prevent excessive cruelty have been rendered largely ineffectual, as their membership is stacked predominantly with animal researchers.

Most animal experiments on monkeys, dogs, cats and other animals are not related to human benefit, and describing such research as “humane” requires an Orwellian-newspeak definition of the word. “Humane” means to treat with kindness, consideration, or mercy, and as long as words have meanings that cannot be twisted Humpty Dumpty-like into whatever we want them to mean, animal experimentation is not and can never be humane.

Lawrence A. Hansen is a board-certified pathologist and neuropathologist and a professor neuroscience and pathology at the University of California at San Diego, where he also leads the neuropathology core of the Alzheimer Disease Research Center. In March 2009, he was recognized by the Journal of Alzheimer’s Disease as one of the top 100 Alzheimer’s disease investigators in the world. This article originally appeared in the Chicago Tribune, and is reprinted with permission from PETA.

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Pat
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This is ridiculous propaganda. Many, many breakthroughs in medical research over the past several decades have only been possible because of animal research. And Alzhheimer's research is done with monkeys because their brains have many areas that are homologous with our human brain. The author claims that monkeys are "tortured" by researchers but this is patently false. When lesions are made, they are done with drugs; and they are temporary and reversible. PETA would love stop all research involving animals but before considering about siding with them, please think about the older family and friends you know who have passed away because of disease and sickness that we are now making considerable progress toward curing. And think of those you know who have been sick with diseases like cancer, heart disease, and the various brains diseases like Parkinson's who are still alive thanks to medical research. The views expressed in this article are a strong fit with the idealogically warped Bush policies that are being swept aside and reversed by more enlightened politicians in the U.S. now that the republicans are out of power. Maybe PETA is able to sway the young and idealistic during their teens and early 20s who have that wonderful feeling of immortality. But those of us older folks who have lost family and friends, and have seen other helped and cured by recent medical breakthroughs want no part of the foolishness in this article.
 
ducksrock
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More cures for diseases would have been discovered by now if we don't use animals models to create medication for humans. No one would consider taking their dog's medication when they feel ill so why trust medication tested on animals? Pharmaceutical companies and vivisectors are not interested in helping humans. They are interested in helping their own pocket books.
 
cody
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cool article. it's too bad there are still people (masochists?) so obsessed with harming animals in the name of science.
 
Pat
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I have tried to post comments disagreeing with this article and have been blocked so far. It makes me wonder if the Georgia Straight is pro-PETA and is not allowing dissenting views. If so, that's quite sad and, hopefully, with this attempt, I will get a different moderator who will let this comment appear. But if you decide to block my comment again, please delete my account and unregister me as Georgia Straight reader. I won't be back, and you can be sure that I will tell my students in lectures and my colleagues about this newspaper’s bias against medical research.

While this article is crafted to tug at the heartstrings, it omits any mention of the many many breakthoughs made over the past several decades by medical researchers that were only possible because of animal research.

The reason why we know as much as we do about the human brain is because so many areas of the monkey brain are homologous to ours. And without the knowledge we’ve gained from studying animals, we would be far behind where we are today in our efforts to treat and cure brain diseases like Parkinson’s and stroke and Alzheimer’s.

The article describes a type of experiment in which monkey’s heads are stabilized. This is one example of animal research I agree. But the author is implying to readers that most experiments are similar to it. This is not true. Tens of thousands of different medical experiments involving monkeys have been conducted over the years, and very few are this invasive. When lesions are made, this is done with a drug, and the effects are temporary and reversible.

The benefits of animal research far outweigh the costs. Before considering siding with the PETA point of view about banning animal research, please think about older family and friends you have known with cancer and heart disease and brain disease. Medical breakthroughs and even cures are being discovered at an astonishing rate in recent years, and this is due in large part to research involving animals.
 
Sook
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Animal cruelty is wrong but I do not support PETA! Because they are far too much. PETA's calling for the complete ban of all fishing, both commercial and recreational..ridiculous!
I don't know what they're trying to accomplish.
The PETA believes that animals are just like people. They are against: meat, milk, fishing, hunting and several other things. This is a group of people who want to see that animals are made equivalent to humans. Urgggg! I rather care for my family and friends who have heart disease and cancer than a RAT or monkey.
 
ducksrock
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Pat, not only are you misguided, you are completely paranoid. Do you think someone is actually being paid to sit there on a Saturday to read your long winded rant and blocking you? I think most media outlets do not have a spending budget like the pharmaceutical companies and universities that you are used to. And if they're blocking you, you wouldn't be the single person on this forum who has written more words than everyone else combined.

People who care about their families do not have to accept faulty science. People are dying everyday from horrible side-effects from taking pharmaceuticals created from animal testing. Millions of people are dying every single day from cancer and diseases because science is held back by disingenuous vivisectors and pharmaceuticals who are not really looking for cures. It's a shame that billions of dollars have been spent in research with so little advancements. Why is there still no cure for cancer or AIDS if science is so advanced? Why should people accept that they will die from these illnesses after billions of dollars have been spent on researching the subject?
 
Roger Hardin
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Shame on the Georgia Straight is becoming a mouthpiece for PETA disinformation and propaganda.

 
Sook
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I think you are the one who are paranoid Ducksrock..and you are the one who are misinformation. I have friends and family that were cured and helped. If it is not because of advanced science - they have been dead long time. You probably have a point about pharmaceuticals companies...millions of people have been diagnose that they have cancer and illness but they were people I know that were helped and really thankful. You probably talking about US pharmaceuticals companies... no wonder. If you are supporting PETA - shame on you!
 
Chris D. from B.C.
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People who care about their families and friends will do anything - I mean will try anything and will not lose hope. My grandmother had cancer, and some of my relatives but the good thing - it was diagnos earlier, the doctor were able to removed the tumor. There is no perfect science and I don't think that supporting PETA is a better solution to avoid people from dying or getting illness or disease. FYI, we are in now in an ERA that somehow the advanced science have helped millions of people too. Besides we have all the reources to do research and find information. Obviously you DUCKROCKS are the one who are misguided, besides to whom do you want to test these drugs, I better choose to test drugs to animals instead on humans. I don't care about RATS...(I care about dogs - I have dogs) and animals cannot be level as human. You don't care about other people, you want them to just accept and wait till they die from their illnesses - is that the best you can do!
And what are you saying "spent in research with so little advancements" OMG - you are the one who are really misinformed....LOL!
 
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