Broke, alone and facing foreclosure on his business, Earl Stone (Clint Eastwood) takes a job as a drug courier for a Mexican cartel. His immediate success leads to easy money and a larger shipment that soon draws the attention of hard-charging DEA agent, Colin Bates (Bradley Cooper). When Earl's past mistakes start to weigh heavily on his conscience, he must decide whether to right those wrongs before law enforcement and cartel thugs catch up to him.