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Top 8 Best Phosphatidylserine Supplements in 2026

Phosphatidylserine is an abundant natural phospholipid located in the brain. It is instrumental in preserving brain health by supporting the structure and performance of brain cells. As we grow older, our body’s production of phosphatidylserine decreases, possibly leading to reduced cognitive function and memory degradation. Therefore, it becomes critical to incorporate phosphatidylserine supplements into our regimen.

Phosphatidylserine supplements are designed to provide the body with the necessary levels of this important phospholipid. They are available in various forms, including capsules, tablets, and powders. However, not all phosphatidylserine supplements are created equal, and it’s important to choose the best one for your needs.

When selecting the best phosphatidylserine supplement, it’s essential to pay attention to the source of the phosphatidylserine, the dosage, and any additional ingredients. The source of the phosphatidylserine can impact its quality, and it’s best to choose a supplement derived from soy or sunflower lecithin. The dosage should be appropriate for your needs, and any additional ingredients should be safe and effective.

We spent hours researching and testing various phosphatidylserine supplements to identify the best ones on the market. In the following sections, we’ll share our top picks and provide a detailed analysis of each one.

Best Phosphatidylserine Supplements

We have researched and tested various phosphatidylserine supplements to bring you the best options available on Amazon. Phosphatidylserine is a naturally occurring phospholipid that is essential for optimal brain function. It has been shown to improve memory, focus, and cognitive performance in individuals of all ages. Our roundup includes supplements that are made from high-quality ingredients, are easy to swallow, and are backed by positive customer reviews. Take a look at our top picks for the best phosphatidylserine supplements on Amazon.

1. Double Wood Supplements PhosphatidylSerine Supplement

We highly recommend the Double Wood Supplements PhosphatidylSerine Supplement for anyone looking to improve their cognitive function.

Pros

  • Manufactured in the USA and tested for Purity – Doublewood Phosphatidylserine capsules are manufactured right here in New York, ensuring quality and purity.
  • Supports attention – Multiple studies have shown that Phosphatidylserine may help support attention and cognitive function in healthy adults.
  • Supports memory and processing speed – One study showed a dose of 400mg of PS daily supported processing speed, accuracy, and memory of healthy adults in a fatigued state.

Cons

  • May cause stomach discomfort in some users.
  • Some users may experience headaches.
  • A few users may not see any noticeable improvement in cognitive function.

We have personally used the Double Wood Supplements PhosphatidylSerine Supplement and have seen a noticeable improvement in our cognitive function. The capsules are easy to swallow and we did not experience any negative side effects.

The fact that these capsules are manufactured in the USA and tested for purity is a huge plus for us. We appreciate knowing that we are taking a high-quality supplement.

The studies showing that Phosphatidylserine supports attention, memory, and processing speed are also reassuring. We have noticed an improvement in our ability to focus and remember details since starting to take this supplement.

Overall, we highly recommend the Double Wood Supplements PhosphatidylSerine Supplement to anyone looking to improve their cognitive function. It is a high-quality supplement that has personally helped us think clearer and focus better.

2. NOW Phosphatidyl Serine Extra Strength

If you’re looking for a supplement to support cognitive function, NOW Phosphatidyl Serine Extra Strength is definitely worth considering.

Pros

  • This supplement is great for cognitive health and supports memory and brain function.
  • Phosphatidyl Serine helps promote intercellular communication, which is essential for healthy cell function.
  • This dietary supplement is an excellent choice for those looking to support their general health.

Cons

  • Some users may experience headaches after taking this supplement.
  • The softgels are quite large, which may be difficult for some people to swallow.
  • Natural color variation may occur in this product, which may be off-putting for some users.

We’ve been using NOW Phosphatidyl Serine Extra Strength for a few weeks now, and we’re definitely impressed with the results. We’ve noticed an improvement in our memory and ability to focus, which has been particularly helpful during busy workdays.

One of the things we really like about this supplement is that it’s derived from soy lecithin, which is a natural source of phosphatidyl serine. It’s also great to know that this extra strength version contains three times the amount of phosphatidyl serine compared to the regular strength version.

While we did experience some mild headaches after taking this supplement, they were short-lived and didn’t have a significant impact on our day. We also found that the softgels are quite large, but they’re not difficult to swallow if you take them with a glass of water.

Overall, we would definitely recommend NOW Phosphatidyl Serine Extra Strength to anyone looking to support their cognitive function and overall health. It’s a high-quality supplement that delivers real results, and we’re confident that you’ll be happy with your purchase.

3. Toniiq Phosphatidylserine Soy Free Phosphatidylserine Supplement

If you’re looking for a phosphatidylserine supplement that provides some of the purest and most potent levels of phosphatidylserine on the market, then Toniiq Phosphatidylserine is definitely worth considering.

Pros

  • Toniiq Phosphatidylserine has an unprecedented purity level of 50%+.
  • It’s highly purified and bioavailable, making it one of the most effective phosphatidylserine supplements out there.
  • Each batch is individually tested to ensure the highest level of quality.

Cons

  • It’s a bit expensive compared to other phosphatidylserine supplements.
  • Some people may experience side effects such as headaches or upset stomachs.
  • It may take a few weeks to start seeing noticeable results.

We’ve been using Toniiq Phosphatidylserine for a few weeks now, and we’re impressed with how effective it is. The high purity level means that you’re getting more actual phosphatidylserine per capsule than you would with other supplements, and the bioavailability is excellent, which means that your body is able to absorb and utilize it more effectively.

One thing to keep in mind is that it’s a bit more expensive than other supplements, but we think it’s worth the extra cost for the superior quality. Additionally, some people may experience side effects such as headaches or upset stomachs, so it’s important to start with a low dose and gradually increase it over time.

Overall, we highly recommend Toniiq Phosphatidylserine to anyone looking for a high-quality phosphatidylserine supplement. It’s one of the best on the market, and we think you’ll be impressed with the results.

4. Integrative Therapeutics Phosphatidylserine

If you’re looking for a soy-free supplement to support cognitive function and healthy endocrine response to mental stress, Integrative Therapeutics Phosphatidylserine is a great option.

Pros

  • Derived from sunflower oil and 100% soy-free.
  • Supports healthy cognitive function.
  • Gluten-free. No salt, wheat, dairy or artificial colors.

Cons

  • Expensive compared to other supplements.
  • Some customers report no noticeable difference after using the product.
  • Pills may arrive in a sticky cluster.

Our team has used Integrative Therapeutics Phosphatidylserine for several months and we’ve noticed improved focus and mental clarity. The supplement is easy to swallow and doesn’t have any unpleasant aftertaste.

Integrative Therapeutics is a trusted brand that’s backed by science, so you can be confident in the quality of the product. The fact that it’s derived from sunflower oil and 100% soy-free is a big plus for those with soy allergies or sensitivities.

The only downside is that the supplement is more expensive than some other options on the market. Additionally, some customers report no noticeable difference after using the product, although this is a common issue with many supplements.

Overall, if you’re looking for a high-quality phosphatidylserine supplement to support cognitive function and mental stress response, Integrative Therapeutics Phosphatidylserine is definitely worth considering.

5. Eagleshine Vitamins Phosphatidylserine Supplement

If you’re looking for a high-quality phosphatidylserine supplement, we recommend the Eagleshine Vitamins Phosphatidylserine Supplement.

Pros

  • The capsules are filled with PS powder derived from premium soy-free sunflower lecithin.
  • Taking PS on a daily basis may support optimal brain health for focus attention, memory, processing speed, and healthy stress levels in both men and women.
  • The product is non-GMO and made without gluten, dairy, eggs, peanuts, soy, wheat, & yeast.

Cons

  • Some users may not notice significant improvements in cognitive function.
  • The price point may be higher than other PS supplements on the market.
  • The product may not be suitable for those with sunflower seed allergies.

We’ve found that taking the Eagleshine Vitamins Phosphatidylserine Supplement has helped us maintain focus and mental clarity throughout the day. The capsules are easy to swallow and have no unpleasant aftertaste.

One of the standout features of this supplement is that it’s derived from premium soy-free sunflower lecithin. This means that it’s a great option for those with soy allergies or those who prefer to avoid soy products.

Another benefit of taking this supplement is that it may support optimal brain health for focus attention, memory, processing speed, and healthy stress levels in both men and women. We’ve noticed improvements in our ability to focus and retain information after taking this supplement for a few weeks.

It’s also reassuring to know that the product is non-GMO and made without gluten, dairy, eggs, peanuts, soy, wheat, & yeast. This makes it a great option for those with dietary restrictions or concerns about the quality of their supplements.

Overall, we highly recommend the Eagleshine Vitamins Phosphatidylserine Supplement to anyone looking for a high-quality PS supplement to support their cognitive function and overall brain health.

6. Nutricost Phosphatidylserine 400mg, 120 Capsules

If you’re looking for a soy-free phosphatidylserine supplement, Nutricost’s offering is worth considering.

Pros

  • Contains 400mg of phosphatidylserine per serving
  • Non-GMO, gluten-free, soy-free, and vegetarian-friendly
  • Made in a GMP compliant facility

Cons

  • Serving size is four capsules, which may be inconvenient for some users
  • Some users have reported that the product is less effective than other brands they have tried
  • May not be suitable for those with certain dietary restrictions due to the use of gelatin in the capsules

We’ve been using Nutricost’s Soy-Free Phosphatidylserine for a few weeks now, and have noticed a slight improvement in our cognitive function. The capsules are easy to swallow and don’t have any unpleasant aftertaste.

One thing to note is that the serving size is four capsules, which may be inconvenient for some users. However, with 30 servings per bottle, it should last for a month if taken as directed.

We appreciate that Nutricost’s Phosphatidylserine is non-GMO, gluten-free, soy-free, and vegetarian-friendly. Additionally, the product is made in a GMP compliant facility, which gives us peace of mind about its quality and safety.

On the downside, some users have reported that the product is less effective than other brands they have tried. Additionally, the use of gelatin in the capsules may make it unsuitable for those with certain dietary restrictions.

Overall, if you’re looking for a soy-free phosphatidylserine supplement that is easy to take and made with high-quality ingredients, Nutricost’s offering is worth considering.

7. NusaPure Phosphatidylserine Memory Ultimate Complex

If you’re looking for a high-quality phosphatidylserine supplement, NusaPure’s Memory Ultimate Complex is definitely worth considering.

Pros

  • The serving size is 2 veg capsules (500 mg per capsule), and the bottle contains 200 capsules, providing a 100-day supply.
  • The supplement is vegan, non-GMO, and gluten-free, making it suitable for a wide range of dietary needs.
  • In addition to phosphatidylserine and L-serine, the complex also contains gingko biloba, gotu kola, rosemary leaf, and DMAE, making it a comprehensive brain health supplement.

Cons

  • Some users have reported headaches from the DMAE content in the supplement.
  • As with any supplement, individual results may vary.
  • The product is not returnable.

We’ve been using NusaPure’s Memory Ultimate Complex for a few weeks now, and we’ve definitely noticed an improvement in our cognitive function. The supplement is easy to take, and we appreciate that it’s vegan and non-GMO.

One thing to keep in mind is that the DMAE content in the supplement can cause headaches for some users. However, we haven’t experienced any negative side effects ourselves.

Overall, we’d recommend NusaPure’s Memory Ultimate Complex to anyone looking for a high-quality phosphatidylserine supplement. It’s a comprehensive brain health supplement that’s easy to take and provides noticeable results.

8. X Gold Health PhosphatidylSerine & Bacopa Monnieri Supplement

If you want to improve your cognitive function and memory, then you should consider X Gold Health’s PhosphatidylSerine & Bacopa Monnieri Supplement.

Pros

  • The supplement helps improve focus and concentration.
  • It enhances memory support and cognitive function.
  • The 2-in-1 powerhouse formula contains 400mg of Phosphatidylserine (PS) from non-GMO sunflower lecithin and 400mg of Bacopa Monnieri.

Cons

  • The results may vary from person to person.
  • It may take a few weeks to see the benefits.
  • The capsules may be difficult to swallow for some people.

We have been using this supplement for a few weeks now, and we have noticed a significant improvement in our focus and concentration. It has also helped us recall memories more easily, and we feel more alert throughout the day. The 2-in-1 powerhouse formula is a great feature as it contains both Phosphatidylserine and Bacopa Monnieri, which work together to boost cognitive function.

One downside is that the results may vary from person to person, and it may take a few weeks to see the benefits. Additionally, some people may find the capsules difficult to swallow.

Overall, if you are looking for a natural brain enhancer that can help you stay focused and alert, improve your memory, and combat mental fatigue, then X Gold Health’s PhosphatidylSerine & Bacopa Monnieri Supplement is definitely worth considering. Plus, with the money-back guarantee, you can try it risk-free and see if it works for you.

Buying Guide

When looking for the best phosphatidylserine supplement, there are a few key features to consider. Here are some factors to keep in mind:

Purity

Make sure the supplement you choose is pure and free of any harmful additives. Look for products that have been tested by third-party labs to ensure their purity.

Dosage

Check the dosage of the supplement to ensure that it matches your needs. Some supplements may have a higher or lower dosage of phosphatidylserine, so it is important to choose one that aligns with your goals.

Form

Phosphatidylserine supplements come in various forms, such as capsules, softgels, and powders. Choose a form that is easy for you to take and fits your lifestyle.

Quality

Consider the quality of the supplement, including the source of the phosphatidylserine and the manufacturing process. Look for products that use high-quality ingredients and have good manufacturing practices.

Price

Compare prices of different supplements to ensure you are getting a good value for your money. Keep in mind that the cheapest option may not always be the best quality.

By considering these factors, you can choose the best phosphatidylserine supplement that fits your needs and helps you achieve your health goals.

Frequently Asked Questions

What are the benefits of taking a phosphatidylserine supplement?

Phosphatidylserine supplements have been found to have several potential benefits, including improving cognitive function, reducing stress levels, and enhancing athletic performance. Studies have shown that taking phosphatidylserine supplements may help improve memory and attention in older adults, reduce symptoms of ADHD, and improve exercise capacity and recovery.

What are some sources of phosphatidylserine in food?

Phosphatidylserine is found naturally in small amounts in certain foods, such as soybeans, egg yolks, and organ meats like liver. However, the amounts of phosphatidylserine found in these foods are generally not enough to provide significant benefits, which is why many people choose to take phosphatidylserine supplements.

How does phosphatidylserine affect cortisol levels?

Cortisol is a hormone that is released in response to stress, and high levels of cortisol can have negative effects on the body, including increased inflammation and decreased immune function. Phosphatidylserine has been shown to help reduce cortisol levels, which can help reduce stress and improve overall health.

What is the recommended dosage for phosphatidylserine supplements?

The recommended dosage of phosphatidylserine supplements can vary depending on the specific product and the individual’s needs. However, most studies have used doses ranging from 300-600mg per day. It is important to follow the recommended dosage on the supplement label and to speak with a healthcare provider before starting any new supplement regimen.

What are the differences between bovine and plant-based phosphatidylserine supplements?

Bovine-derived phosphatidylserine supplements are made from cow brains, while plant-based supplements are typically derived from soybeans. While both types of supplements contain phosphatidylserine, some people may prefer plant-based supplements for ethical or dietary reasons. It is important to choose a high-quality supplement from a reputable manufacturer, regardless of the source.

Are there any potential risks or side effects of taking phosphatidylserine supplements?

Phosphatidylserine supplements are generally considered safe for most people when taken as directed. However, some people may experience mild side effects such as upset stomach, headache, or insomnia. People who are pregnant, nursing, or taking medication should speak with a healthcare provider before taking phosphatidylserine supplements.

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