Researcher Alan Cassels scrutinizes medical screening tests in new book Seeking Sickness

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      For a lot of people, their health is defined, in part, by a number. What is their cholesterol level? What is their body-mass index? For those with concerns about osteoporosis, there’s a “T-score”, which measures bone density. Most recently, there was a flurry of news reports about PSA tests, which calculate levels of a prostate-specific antigen.

      University of Victoria pharmaceutical-policy researcher Alan Cassels calls these numbers “surrogate markers”. They supposedly offer a clue into the risk of developing an underlying condition—such as a heart attack, stroke, bone disease, or prostate cancer—but he insists that this isn’t always the case.

      “Frankly, a lot of the drugs and a lot of the tests are marketed on their ability to check what this surrogate marker is…without really altering the underlying condition,” Cassels says by phone from his home in Victoria.

      In his new book, Seeking Sickness: Medical Screening and the Misguided Hunt for Disease (Douglas & McIntyre), Cassels offers a consumer’s guide to an array of tests covering various diseases, including many forms of cancer. There are separate chapters on breast and lung testing, indicating risks that the general public may not be aware of. Colon- and cervical-cancer screening also receives a great deal of attention, as do the potential consequences of having a biopsy. And there are some frightening stories about the downside of having your cholesterol checked.

      On the upside, Cassels says the Pap smear is the test that saves the most lives and is backed by the best science. “Cervical cancer is something you can detect early,” he states. “You can do something to change the course of the disease. And what you do is not going to have other serious side effects.”

      In his book, he also explores eye exams, mental-health screening, and genetic testing. Readers discover that sometimes, these tests convince physicians to take action that can cause more harm than good.

      A classic example is the PSA test, which helps doctors diagnose prostate cancer. Earlier this week, the United States Preventive Services Task Force published a paper in the peer-reviewed Annals of Internal Medicine recommending against this screening method for asymptomatic men of any age.

      “Strong evidence shows that PSA screening is associated with significant harms,” the USPSTF stated. “Nearly 90 percent of men with PSA-detected prostate cancer undergo early treatment with surgery, radiation, or androgen deprivation therapy. Evidence shows that up to five in 1,000 men will die within one month of prostate cancer surgery and between 10 and 70 men will survive, but suffer life-long adverse effects such as urinary incontinence, erectile dysfunction, and bowel dysfunction.”

      It’s a recommendation that Cassels agrees with. “The fact that one of the biggest organizations in the U.S. that advises on screening is giving a major thumbs down to one of the most popular forms of cancer screening—this is a pretty big deal,” he says. “It’s been in the works for a long time. I totally agree with it because they’re finally recognizing that when you quantify the benefits and the harms, you’re helping very few men by screening them for prostate cancer.”

      He adds that there’s a difference in the way prostate cancer is often treated in the United States, compared with in this country. “In the U.S., it’s really seen to be a serious moneymaker,” Cassels says. “You’ve got hospitals and cancer centres buying these big robots—these high-tech $5-million robots—and then they market this as the cleanest, best way to get your prostate removed.”

      He bluntly writes in his book that “urologists have an unavoidable conflict of interest regarding PSA screening because…so much of their work depends on treating prostate cancer when they see it.” Therefore, he suggests, it is hard for them to be critical of these tests. However, Cassels points out that studies have demonstrated that men whose prostate cancers are revealed through these diagnostic examinations do not live longer than those whose cancers were discovered in other ways.

      One of the more entertaining sections of the book concerns self-screening for diseases over the Internet. He reports in the book that pharmaceutical companies sometimes put simple tests online with the goal of encouraging people to see their doctor to receive more tests. The ultimate objective is to sell more prescription drugs.

      “You can imagine [Straight sex columnist] Dan Savage giving you a test with five questions to see if you’re sexually repressed,” Cassels says with a laugh. “It’s easy to answer ‘yes’ to several of the questions. In the case of a lot of these tests, the punch line is see your doctor, who would order a screen or prescribe a drug, right?”

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      Jul 24, 2012 at 10:41am

      excellent - this is a perspective I share - I am a health and fitness educator - I try to get women to really assess their risk factors to make a balanced and informed decidion about this stuff but it is very hard to convince them as they have been so brainwashed.

      Victor Winston

      Aug 9, 2012 at 11:59am

      I am one of those asymptomatic PSA testing "victim".
      Diagnosed with PSA 6,"brainwashed" into High Dose External Beam Radiationwith a seeming success,BUT after 3 years resulted in "Biological failure"
      PSA up again and now on Hormonal Therapy with all those undesirable side effects
      the worst this treatment equals chemical CASTRATION.
      I escaped radical surgery,that has a potential to render the"victim" IMPOTENT and INCONTINENT until the rest of life.
      The joke here is that I worked as a researcher at the same University
      Alan Cassels,the author works--without unfortunately knowing him .
      The Politics and Business of Prostate Cancers should be made more public,
      this book is already helping!

      victoria bc resident

      Nov 17, 2012 at 4:55pm

      My PSA has been rising for about a year now. The last test, a month ago, was 7.5. The rectal exam reveals nothing abnormal. I've been advised by a urologist to have a prostate biopsy several months ago. I declined. I feel fine and don't have symptoms such as numerous trips to the bathroom at night, noticeably weak urine stream etc...but I am conscious of these things. I seem to notice an odd smell to the urine...I don't know. My mind is always working overtime on this issue. I'm waiting and watching. I've read many articles on the effectiveness of the PSA test, or lack thereof...I'm sticking to my guns....for now.

      Canadian Breast Cancer Foundation

      May 15, 2014 at 1:39pm

      It’s time to end the debate about mammography because there is nothing to debate. There is a 25% reduction in breast cancer mortality amongst women who screen regularly. Mammograms save lives.

      Keith Loreth

      Aug 4, 2014 at 1:30pm

      My opinion is to have good levels of zinc and copper and also selenium for a healthy prostate.There are also lots of other nutrients that may be helpful.