According to Drive B.C., Highway 1 will remain closed until around 2 a.m. in part of North Vancouver.
A three-vehicle crash near the bottom of the Cut has shut down the road between the Lynn Valley and Mountain Highway exits.
Global B.C. News has reported that one person died.
Flames were seen from a fair distance away after the head-on collision.
Meanwhile, motorists are being urged to avoid the Ironworkers Memorial Second Narrows Crossing and go over the Lions Gate Bridge instead.