Princess Cruises has issued a statement providing details about a tragedy nearly 13 kilometres from Ketchikan, Alaska.
Two float planes each carrying passengers from the Royal Princess collided in mid-air this afternoon.
One plane had 10 guests and a pilot; the other plane had four guests, and they were on sightseeing flights at the time of the crash.
According to Princess Cruises, five people have died. The Coast Guard has said that another person is missing.
Meanwhile, the Alaska Star has reported that 10 people have been hospitalized.
"We are incredibly distressed by this situation, and our thoughts and prayers are with those onboard the planes and their families," the company said. "Princess Cruises is extending its full support to travelling companions of the guests involved."
The ship left Vancouver on May 11. The Royal Princess can carry 3,560 guests and has 1,346 crew members.
Global Affairs Canada has confirmed that one Canadian is among the dead.